Emily (Academy Award nominee Rooney Mara) and Martin Taylor (Channing Tatum) are a young, beautiful, wealthy couple living the good life, with a mansion, a sailboat and every luxury money can buy—until Martin is sent to prison for insider trading. For four years, Emily waits for him in a tiny apartment in upper Manhattan, but his release is just as devastating as his incarceration and Emily sinks into a deep depression.
After a failed suicide attempt, psychiatrist Jonathan Banks (Academy Award nominee Jude Law) is called in to consult on Emily’s case. Desperate not to be hospitalized, Emily agrees to a regimen of therapy and antidepressants, a decision that will change the lives of everyone involved. When Emily’s symptoms don’t improve, Banks prescribes a new medication that quiets her demons. But the side effects of the drug have chilling consequences: marriages are ruined, Banks’ practice is decimated and someone is dead—but who is responsible? Devastated by this professional setback, Banks becomes obsessed with finding an answer. But the truth he uncovers threatens to destroy whatever is left of his career and his private life.